Συντάχθηκε 17-06-2014 10:43
από Dafni Manousaki
Email συντάκτη: dmanousaki<στο>tuc.gr
Ενημερώθηκε:
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Ιδιότητα: ΔΕΠ ΗΜΜΥ.
Invited Speaker Lecture
Title:
Investigation of the phenotypic plasticity effect on tumor growth: the Go or Grow mechanism
Friday, June 20th, 2014
13:00-14:00
Main Amphitheatre, School of Electronic and Computer Engineering
Speaker:
Haralampos Hatzikirou, PhD
Multiscale Modeling of Multicellular Systems (M^3s)
Group leader
cfAED (center for Advancing Electronics in Dresden)
Abstact:
Tumor cells possess a remarkable phenotypic plasticity that allows adaptation to changing environmental conditions. Prominent examples are the epithelial-mesenchymal transition and the shift towards glycolitic, anaerobic cell metabolism, known as Warburg effect. A further example is phenotypic plasticity with respect to cell proliferation and migration, a phenomenon known as go-or-grow mechanism. Our work suggested that local cell density is a key factor for the regulation of the switch based on experimental results. However, potential effects of a density-dependent switch between migratory and proliferative phenotypes on tumor growth have not been investigated so far. To address this problem, we formulate and study a mathematical model of spatio-temporal tumor dynamics where different responses to local cell density mediate the go-or-grow dichotomy. Our analysis reveals that different dynamic regimes can be distinguished. We discuss potential implications of our findings for the interpretation of recent experiments on tumor progression and for the design of new tumor therapies.
